N., Tang, M., Svirskis, D., Chamley, L., & Wu, Z
Study Design 441 adults with obesity received tirzepatide for 60 weeks Participants who achieved meaningful weight loss were then randomized for another 52 weeks to: Continue maximum tolerated dose (1015 mg) Reduce to 5 mg Switch to placebo Weight Loss at Week 112 Continued max dose: 21.9% total body weight Reduced to 5 mg: 16.6% Placebo/discontinuation: 9.9% Weight regain was common after stopping therapy Participants regaining 50% of lost weight: 8% on continued max dose 25% on 5 mg 67% after discontinuation Cardiometabolic benefits were also maintained Including improvements in: Waist circumference Blood pressure Glycemia Lipid profile so whats the best for patients after hitting the target weight loss
Yet, "one of the most common misconceptions that I see is that this is a medication that is intended to be taken until an individual reaches their goal weight and then they can stop," says Dominguez
And shame is the exact same thing that will send me right back into the pantry
Do B12 shots affect your heart
This study suggests that deoxygenated haemoglobin catalyses the reduction of nitrite to NO in the human circulation to regulate vascular tone